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TNF superfamily member TL1A elicits type 2 innate lymphoid cells at mucosal barriers

13 Nov 2013

Abstract excerpt

Immune responses at mucosal barriers are regulated by innate type 2 lymphoid cells (ILC2s) that elaborate effector cytokines interleukins 5 and 13 (IL5 and IL13). IL25 and IL33 are key cytokines that support ILC2s; however, mice deficient in these pathways retain some functional ILC2s. Analysis of human and murine cells revealed that ILC2s highly express tumor necrosis factor (TNF)-receptor superfamily member DR3...

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PMID: 24220298
DOI: 10.1038/mi.2013.92

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