Article
Cytoplasmic retention of the DNA/RNA-binding protein FUS ameliorates organ fibrosis in mice.
The Journal of clinical investigation - 15 Mar 2024
Chiusa Manuel, Lee Youngmin A, Zhang Ming-Zhi, Harris Raymond C, Sherrill Taylor, Lindner Volkhard, Brooks Craig R, Yu Gang, Fogo Agnes B, Flynn Charles R, Zienkiewicz Jozef, Hawiger Jacek, Zent Roy, Pozzi Ambra
Abstract excerpt
Uncontrolled accumulation of extracellular matrix leads to tissue fibrosis and loss of organ function. We previously demonstrated in vitro that the DNA/RNA-binding protein fused in sarcoma (FUS) promotes fibrotic responses by translocating to the nucleus, where it initiates collagen gene transcription. However, it is still not known whether FUS is profibrotic in vivo and whether preventing its nuclear...
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