Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Fus deficiency in mice results in defective B-lymphocyte development and activation, high levels of chromosomal instability and perinatal death.

Nature genetics - 1 Feb 2000

Hicks G G, Singh N, Nashabi A, Mai S, Bozek G, Klewes L, Arapovic D, White E K, Koury M J, Oltz E M, Van Kaer L, Ruley H E

Abstract excerpt

The gene FUS (also known as TLS (for translocated in liposarcoma) and hnRNP P2) is translocated with the gene encoding the transcription factor ERG-1 in human myeloid leukaemias. Although the functions of wild-type FUS are unknown, the protein contains an RNA-recognition motif and is a component of nuclear riboprotein complexes. FUS resembles a transcription factor in that it binds DNA, contributes a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animals, Newborn
Share to Bone Marrow Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chimera

Share to Heterogeneous-Nuclear Ribonucleoproteins

Share to Lymphocyte Activation

Share to Ribonucleoproteins

Share to RNA-Binding Protein FUS

Share to Spleen

Source

Identifiers

PMID: 10655065
DOI: 10.1038/72842

Genes

FUS
ERG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Fus deficiency in mice results in defective B-lymphocyte development and activation, high levels of chromosomal instability and perinatal death.PMID 10655065Read ↗

Functions of FUS/TLS From DNA Repair to Stress Response: Implications for ALSSemantic proximity Read ↗

fus/TLS orchestrates splicing of developmental regulators during gastrulation.Semantic proximity Read ↗

Wild-Type and Mutant FUS Expression Reduce Proliferation and Neuronal Differentiation Properties of Neural Stem Progenitor Cells.Semantic proximity Read ↗

Characterization of genetic loss-of-function of Fus in zebrafish.Semantic proximity Read ↗

Identification of a novel FUS/ETV4 fusion and comparative analysis with other Ewing sarcoma fusion proteinsSemantic proximity Read ↗

FET fusion oncoproteins disrupt physiologic DNA repair networks and induce ATR synthetic lethality in cancerSemantic proximity Read ↗

Gene Expression Responses to FUS, EWS, and TAF15 Reduction and Stress Granule Sequestration Analyses Identifies FET-Protein Non-Redundant FunctionsSemantic proximity Read ↗

Toxic gain of function from mutant FUS protein is crucial to trigger cell autonomous motor neuron loss.Semantic proximity Read ↗

Generation of a heterozygous FUS-Q290X knock in human embryonic stem cell line (WAe009-A-83) using CRISPR/Cas9 system.Semantic proximity Read ↗

FUS (fused in sarcoma) is a component of the cellular response to topoisomerase I–induced DNA breakage and transcriptional stressSemantic proximity Read ↗

FUS Unveiled in Mitochondrial DNA Repair and Targeted Ligase-1 Expression Rescues Repair-Defects in FUS-Linked NeurodegenerationSemantic proximity Read ↗

FUS unveiled in mitochondrial DNA repair and targeted ligase-1 expression rescues repair-defects in FUS-linked motor neuron disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.