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Article

Nucleic acid binding proteins affect the subcellular distribution of phosphorothioate antisense oligonucleotides.

Nucleic acids research - 13 Oct 2017

Bailey Jeffrey K, Shen Wen, Liang Xue-Hai, Crooke Stanley T

Abstract excerpt

Antisense oligonucleotides (ASOs) are versatile tools that can regulate multiple steps of RNA biogenesis in cells and living organisms. Significant improvements in delivery, potency, and stability have been achieved through modifications within the oligonucleotide backbone, sugar and heterocycles. However, these modifications can profoundly affect interactions between ASOs and intracellular proteins in ways that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Oligonucleotides, Antisense

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Share to RNA-Binding Protein FUS

Source

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Identifiers

PMID: 28977508
DOI: 10.1093/nar/gkx709
PMCID: PMC5737868

Genes

FUS
SFPQ

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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