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Article

Mutant FUS induces chromatin reorganization in the hippocampus and alters memory processes.

Progress in neurobiology - 1 Aug 2023

Tzeplaeff Laura, Seguin Jonathan, Le Gras Stéphanie, Megat Salim, Cosquer Brigitte, Plassard Damien, Dieterlé Stéphane, Paiva Isabel, Picchiarelli Gina, Decraene Charles, Alcala-Vida Rafael, Cassel Jean-Christophe, Merienne Karine, Dupuis Luc, Boutillier Anne-Laurence

Abstract excerpt

Cytoplasmic mislocalization of the nuclear Fused in Sarcoma (FUS) protein is associated to amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Cytoplasmic FUS accumulation is recapitulated in the frontal cortex and spinal cord of heterozygous Fus∆NLS/+ mice. Yet, the mechanisms linking FUS mislocalization to hippocampal function and memory formation are still not characterized. Herein, we show...

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Source

Identifiers

PMID: 37327984
DOI: 10.1016/j.pneurobio.2023.102483

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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