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Article

Extensive splicing changes in an ALS/FTD transgenic mouse model overexpressing cytoplasmic fused in sarcoma.

Scientific reports - 17 Mar 2020

Ito Daisuke, Taguchi Ryota, Deguchi Maki, Ogasawara Hideaki, Inoue Eiji

Abstract excerpt

Mutations in RNA-binding proteins (RBPs) such as TAR DNA-binding protein 43 (TDP-43) and fused in sarcoma (FUS) are associated with amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Recent evidence suggests that RNA dysregulation mediated by aberrant RBPs may play a critical role in neurodegeneration, but the underlying molecular mechanisms are largely unknown. In this study, we performed...

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Identifiers

PMID: 32184412
DOI: 10.1038/s41598-020-61676-x
PMCID: PMC7078223

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