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Streamlined measurement of chimeric antigen receptor T-cell concentration, size, viability and two-color phenotyping during manufacturing.

Cytotherapy - 1 May 2024

Pajarillo Raymone, Paruzzo Luca, Carturan Alberto, Ugwuanyi Ositadimma, White Griffin, Guruprasad Puneeth, Ballard Hatcher J, Patel Ruchi P, Zhang Yunlin, Lee Yong Gu, Hong Seok Jae Albert, Dittami Gregory M, Ruella Marco

Abstract excerpt

BACKGROUND AIMS: The successful development of CD19-targeted chimeric antigen receptor (CAR) T-cell therapies has led to an exponential increase in the number of patients recieving treatment and the advancement of novel CAR T products. Therefore, there is a strong need to develop streamlined platforms that allow rapid, cost-effective, and accurate measurement of the key characteristics of CAR T cells during...

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Share to Antigens, CD19
Share to Cell Size

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Immunophenotyping

Share to Immunotherapy, Adoptive

Share to Receptors, Antigen, T-Cell

Share to Receptors, Chimeric Antigen

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Source

Open in PubMed Open full text

Identifiers

PMID: 38483365
DOI: 10.1016/j.jcyt.2024.01.007
PMCID: PMC11259153

Genes

CD19
CD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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