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Article

Substrate-induced condensation activates plant TIR domain proteins.

Nature - 1 Mar 2024

Song Wen, Liu Li, Yu Dongli, Bernardy Hanna, Jirschitzka Jan, Huang Shijia, Jia Aolin, Jemielniak Wictoria, Acker Julia, Laessle Henriette, Wang Junli, Shen Qiaochu, Chen Weijie, Li Pilong, Parker Jane E, Han Zhifu, Schulze-Lefert Paul, Chai Jijie

Abstract excerpt

Plant nucleotide-binding leucine-rich repeat (NLR) immune receptors with an N-terminal Toll/interleukin-1 receptor (TIR) domain mediate recognition of strain-specific pathogen effectors, typically via their C-terminal ligand-sensing domains1. Effector binding enables TIR-encoded enzymatic activities that are required for TIR-NLR (TNL)-mediated immunity2,3. Many truncated TNL proteins lack effector-sensing domains...

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Identifiers

PMID: 38480885
DOI: 10.1038/s41586-024-07183-9
PMCID: PMC10972746

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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