Article

Targeted degradation of endogenous condensation-prone proteins improves crop performance

2024-11-15

Abstract excerpt

Effective methods, such as CRISPR and RNA interference, exist for modulating gene expression at DNA and RNA levels, but approaches for directly modifying endogenous proteins remain lacking in plants. Here, we develop a targeted condensation-prone-protein degradation (TCD) strategy to eliminate endogenous proteins, particularly those prone to condensation. We identify an E3 ligase, E3TCD1, that degrades itself but...

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Literature Corpus work: a57c3f55-3d2d-5fb3-980e-61e35e6fe425
DOI: 10.1101/2024.11.13.623495

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