Article
Multiple functional self-association interfaces in plant TIR domains.
Proceedings of the National Academy of Sciences of the United States of America - 7 Mar 2017
Zhang Xiaoxiao, Bernoux Maud, Bentham Adam R, Newman Toby E, Ve Thomas, Casey Lachlan W, Raaymakers Tom M, Hu Jian, Croll Tristan I, Schreiber Karl J, Staskawicz Brian J, Anderson Peter A, Sohn Kee Hoon, Williams Simon J, Dodds Peter N, Kobe Bostjan
Abstract excerpt
The self-association of Toll/interleukin-1 receptor/resistance protein (TIR) domains has been implicated in signaling in plant and animal immunity receptors. Structure-based studies identified different TIR-domain dimerization interfaces required for signaling of the plant nucleotide-binding oligomerization domain-like receptors (NLRs) L6 from flax and disease resistance protein RPS4 from Arabidopsis Here we show...
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