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Plant pathogens cleave 2′cADPR to suppress TIR immune signaling

2026-06-16

Abstract excerpt

Small molecules produced by TIR (Toll-interleukin-1 receptor) domains are essential for plant immune signaling. A central TIR-derived signal is 2ʹcADPR, a cyclic ADP-ribose (ADPR) molecule that is generated by plant TIR-domain proteins upon sensing pathogen infection. Here we show that XopQ, a virulence protein widespread in plant pathogenic bacteria, cleaves 2ʹcADPR and converts it into an inactive, linear ADPR m...

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Identifiers and source

Literature Corpus work
c6087760-b8d3-5cae-9930-37e09ff9e259
DOI
10.64898/2026.06.15.732069
Open publication

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Plant pathogens cleave 2′cADPR to suppress TIR immune signalingDOI 10.64898/2026.06.15.732069
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