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Article

AIRE relies on Z-DNA to flag gene targets for thymic T cell tolerization.

Nature - 1 Apr 2024

Fang Yuan, Bansal Kushagra, Mostafavi Sara, Benoist Christophe, Mathis Diane

Abstract excerpt

AIRE is an unconventional transcription factor that enhances the expression of thousands of genes in medullary thymic epithelial cells and promotes clonal deletion or phenotypic diversion of self-reactive T cells1-4. The biological logic of AIRE's target specificity remains largely unclear as, in contrast to many transcription factors, it does not bind to a particular DNA sequence motif. Here we implemented two...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38480882
DOI: 10.1038/s41586-024-07169-7
PMCID: PMC11091860

Genes

AIRE
MAF
NFE2
NFE2L2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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