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Article

Aire

20 Mar 2009

Abstract excerpt

Mutations in the transcriptional regulator, Aire, cause APECED, a polyglandular autoimmune disease with monogenic transmission. Animal models of APECED have revealed that Aire plays an important role in T cell tolerance induction in the thymus, mainly by promoting ectopic expression of a large repertoire of transcripts encoding proteins normally restricted to differentiated organs residing in the periphery. The...

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PMID: 19302042
DOI: 10.1146/annurev.immunol.25.022106.141532

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