Article

Decoding the gene regulatory landscape through multimodal learning of protein-DNA interactions

2025-08-17

Abstract excerpt

The identity of a cell is governed by regulatory proteins binding to the genome to control gene expression. Mapping these genome-wide binding events across thousands of proteins and cell types is essential for understanding development and disease at scale, yet has remained a major experimental and computational barrier. Here we present Chromnitron, a multimodal foundation model that learns the rules of protein-DN...

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Literature Corpus work: f6fccf81-1a86-5cdd-9cbb-6d69fd250555
DOI: 10.1101/2025.08.17.670761

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