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Article

AIRE's CARD revealed, a new structure for central tolerance provokes transcriptional plasticity.

The Journal of biological chemistry - 18 Jan 2008

Ferguson Brian J, Alexander Clare, Rossi Simona W, Liiv Ingrid, Rebane Ana, Worth Catherine L, Wong Joyce, Laan Martti, Peterson Pärt, Jenkinson Eric J, Anderson Graham, Scott Hamish S, Cooke Anne, Rich Tina

Abstract excerpt

Developing T cells encounter peripheral self-antigens in the thymus in order to delete autoreactive clones. It is now known that the autoimmune regulator protein (AIRE), which is expressed in thymic medullary epithelial cells, plays a key role in regulating the thymic transcription of these perip...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17974569
DOI: 10.1074/jbc.M707211200

Genes

AIRE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17974569-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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