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Article

Effect of plateletcrit and methylenetetrahydrofolate reductase (MTHFR) C677T genotypes on folic acid efficacy in stroke prevention.

Signal transduction and targeted therapy - 10 May 2024

Shi Yuncong, Zhang Zhengzhipeng, Wang Binyan, Wang Yu, Kong Xiangyi, Sun Yong, Li Aimin, Cui Yimin, Zhang Yan, Li Jianping, Huo Yong, Huang Hui

Abstract excerpt

Previous studies have shown that low platelet count combined with high plasma total homocysteine (tHcy) increased stroke risk and can be lowered by 73% with folic acid. However, the combined role of other platelet activation parameters and the methylenetetrahydrofolate reductase (MTHFR) C677T genotypes on stroke risk and folic acid treatment benefit remain to be examined. This study aimed to investigate if...

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Identifiers

PMID: 38724491
DOI: 10.1038/s41392-024-01817-0
PMCID: PMC11082186

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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