Article
Effect of folic acid intervention on the change of serum folate level in hypertensive Chinese adults: do methylenetetrahydrofolate reductase and methionine synthase gene polymorphisms affect therapeutic responses?
Pharmacogenetics and genomics - 1 Jun 2012
Qin Xianhui, Li Jianping, Cui Yimin, Liu Zeyuan, Zhao Zhigang, Ge Junbo, Guan Deming, Hu Jian, Wang Yanni, Zhang Fumin, Xu Xin, Wang Xiaobin, Xu Xiping, Huo Yong
Abstract excerpt
OBJECTIVES: To assess the influence of individual methylenetetrahydrofolate reductase (MTHFR) C677T and methionine synthase A2756G polymorphisms on the change of serum folate concentration in response to different dosages and durations of folic acid (FA) supplementation in hypertensive Chinese adults. METHODS: A total of 480 patients with mild or moderate essential hypertension were randomly assigned to three...
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