MTHFR Gene and Serum Folate Interaction on Serum Homocysteine Lowering: Prospect for Precision Folic Acid Treatment.

doi:10.1161/ATVBAHA.117.310211

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MTHFR Gene and Serum Folate Interaction on Serum Homocysteine Lowering: Prospect for Precision Folic Acid Treatment.

Arteriosclerosis, thrombosis, and vascular biology - 1 Mar 2018

Huang Xiao, Qin Xianhui, Yang Wenbin, Liu Lishun, Jiang Chongfei, Zhang Xianglin, Jiang Shanqun, Bao Huihui, Su Hai, Li Ping, He Mingli, Song Yun, Zhao Min, Yin Delu, Wang Yu, Zhang Yan, Li Jianping, Yang Renqang, Wu Yanqing, Hong Kui, Wu Qinhua, Chen Yundai, Sun Ningling, Li Xiaoying, Tang Genfu, Wang Binyan, Cai Yefeng, Hou Fan Fan, Huo Yong, Wang Hong, Wang Xiaobin, Cheng Xiaoshu

Abstract excerpt

OBJECTIVE: This post hoc analysis of the CSPPT (China Stroke Primary Prevention Trial) assessed the individual variation in total homocysteine (tHcy)-lowering response after an average 4.5 years of 0.8 mg daily folic acid therapy in Chinese hypertensive adults and evaluated effect modification by methylenetetrahydrofolate reductase (MTHFR) C677T genotypes and serum folate levels. APPROACH AND RESULTS: This...

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PMID: 29371246
DOI: 10.1161/ATVBAHA.117.310211

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MTHFR

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