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Article

APOE ε4 is associated with decreased synaptic density in cognitively impaired participants.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 May 2024

He Kun, Li Binyin, Wang Jie, Wang Ying, You Zhiwen, Chen Xing, Chen Haijuan, Li Junpeng, Huang Qi, Guo Qihao, Huang Yiyun Henry, Guan Yihui, Chen Kewei, Zhao Jun, Deng Yulei, Xie Fang

Abstract excerpt

INTRODUCTION: We aimed to investigate the effect of apolipoprotein E4 (APOE) ε4 on synaptic density in cognitively impaired (CI) participants. METHODS: One hundred ten CI participants underwent amyloid positron emission tomography (PET) with 18F-florbetapir and synaptic density PET with 18F-SynVesT-1. We evaluated the influence of APOE ε4 allele on synaptic density and investigated the effects of ε4 genotype on...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38477490
DOI: 10.1002/alz.13775
PMCID: PMC11095422

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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