Article

Cognitively Normal APOE ε4 Carriers Have Specific Elevation of CSF SNAP-25

2020-12-10

Abstract excerpt

<title>Abstract</title> <p><bold>Background: </bold>Cerebrospinal fluid (CSF) synaptosomal-associated protein 25 (SNAP-25) and neurogranin are recently described biomarkers for synaptic integrity that are known to be elevated in the CSF of symptomatic Alzheimer disease (AD). Their relationship with Apolipoprotein E (<italic>APOE</italic>) ε4 carrier status, the major genetic risk factor for AD, remains unclear.<b...

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Literature Corpus work: 8d28e7e7-65e0-56bb-83cb-99181f57f42c
DOI: 10.21203/rs.3.rs-122858/v1

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