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Article

Apolipoprotein E4 effects in Alzheimer's disease are mediated by synaptotoxic oligomeric amyloid-β.

Brain : a journal of neurology - 1 Jul 2012

Koffie Robert M, Hashimoto Tadafumi, Tai Hwan-Ching, Kay Kevin R, Serrano-Pozo Alberto, Joyner Daniel, Hou Steven, Kopeikina Katherine J, Frosch Matthew P, Lee Virginia M, Holtzman David M, Hyman Bradley T, Spires-Jones Tara L

Abstract excerpt

The apolipoprotein E ε4 gene is the most important genetic risk factor for sporadic Alzheimer's disease, but the link between this gene and neurodegeneration remains unclear. Using array tomography, we analysed >50000 synapses in brains of 11 patients with Alzheimer's disease and five non-demented control subjects and found that synapse loss around senile plaques in Alzheimer's disease correlates with the burden...

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Identifiers

PMID: 22637583
DOI: 10.1093/brain/aws127
PMCID: PMC3381721

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Source receipt: pubmed, retrieved 7 Sept 2026.

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