Article
Neutralizing IFN-γ autoantibodies are rare and pathogenic in HLA-DRB1*15:02 or 16:02 individuals.
The Journal of clinical investigation - 12 Mar 2024
Peel Jessica N, Yang Rui, Le Voyer Tom, Gervais Adrian, Rosain Jérémie, Bastard Paul, Behere Anish, Cederholm Axel, Bodansky Aaron, Seeleuthner Yoann, Conil Clément, Ding Jing-Ya, Lei Wei-Te, Bizien Lucy, Soudee Camille, Migaud Mélanie, Ogishi Masato, Yatim Ahmad, Lee Danyel, Bohlen Jonathan, Perpoint Thomas, Perez Laura, Messina Fernando, Genet Roxana, Karkowski Ludovic, Blot Mathieu, Lafont Emmanuel, Toullec Laurie, Goulvestre Claire, Mehlal-Sedkaoui Souad, Sallette Jérôme, Martin Fernando, Puel Anne, Jouanguy Emmanuelle, Anderson Mark S, Landegren Nils, Tiberghien Pierre, Abel Laurent, Boisson-Dupuis Stéphanie, Bustamante Jacinta, Ku Cheng-Lung, Casanova Jean-Laurent
Abstract excerpt
BACKGROUNDWeakly virulent environmental mycobacteria (EM) can cause severe disease in HLA-DRB1*15:02 or 16:02 adults harboring neutralizing anti-IFN-γ autoantibodies (nAIGAs). The overall prevalence of nAIGAs in the general population is unknown, as are the penetrance of nAIGAs in HLA-DRB1*15:02 or 16:02 individuals and the proportion of patients with unexplained, adult-onset EM infections carrying...
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