Article
Patients with inhibitory and neutralizing auto-antibodies to interferon-γ resemble the sporadic adult-onset phenotype of Mendelian Susceptibility to Mycobacterial Disease (MSMD) lacking Bacille Calmette-Guerin (BCG)-induced diseases.
Immunobiology - 1 May 2013
Lee Wen-I, Huang Jing-Long, Wu Ting-Shu, Lee Ming-Hsun, Chen I-Jung, Yu Kuang-Hiu, Liu Chien-Ying, Yang Chih-Hsun, Hsieh Meng-Ying, Lin Yi-Ling, Shih Ying-Fan, Jaing Tang-Her, Huang Shih-Chiang, Kuo Tseng-Tong, Ku Cheng-Lung
Abstract excerpt
To recognize patients with inhibitory and neutralizing auto-antibodies to interferon-γ (AutoAbs-IFN-γ) presenting with the sporadic phenotype of Mendelian Susceptibility to Mycobacterial Disease (MSMD) mainly characterized by recurrent intracellular mycobacterium or/and salmonella infections, we comprehensively investigated IL12/23-IFN-γ signaling, candidate genetic sequencings or/and protein expressions of...
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