Article
Anti-IFN-γ autoantibodies underlie disseminated Talaromyces marneffei infections.
The Journal of experimental medicine - 7 Dec 2020
Guo Jing, Ning Xin-Qiang, Ding Jing-Ya, Zheng Yan-Qing, Shi Na-Na, Wu Feng-Yao, Lin You-Kun, Shih Han-Po, Ting He-Ting, Liang Gang, Lu Xiang-Chan, Kong Jin-Ling, Wang Ke, Lu Yi-Bo, Fu Yu-Jiao, Hu Rong, Li Tian-Min, Pan Kai-Su, Li Xiu-Ying, Huang Chun-Yang, Lo Yu-Fang, Chang Ian Yi-Feng, Yeh Chun-Fu, Tu Kun-Hua, Tsai Yu-Huan, Ku Cheng-Lung, Cao Cun-Wei
Abstract excerpt
Talaromyces marneffei causes life-threatening opportunistic infections, mainly in Southeast Asia and South China. T. marneffei mainly infects patients with human immunodeficiency virus (HIV) but also infects individuals without known immunosuppression. Here we investigated the involvement of anti-IFN-γ autoantibodies in severe T. marneffei infections in HIV-negative patients. We enrolled 58 HIV-negative adults...
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