Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Novel protective effect of the FOXO3 longevity genotype on mechanisms of cellular aging in Okinawans

8 Mar 2024

Abstract excerpt

The genetic association of FOXO3 genotypes with human longevity is well established, although the mechanism is not fully understood. We now report on the relationship of the FOXO3 longevity variant rs2802292 with telomere length, telomerase activity, FOXO3 expression, and inflammatory cytokine levels in men and women. In agreement with earlier work, the FOXO3 longevity variant conferred protection against...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to FOXO transcription factor regulation
Share to Genetics, Aging, and Longevity in Model Organisms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Telomeres, Telomerase, and Senescence

Source

Identifiers

PMID: 38459055
DOI: 10.1038/s41514-024-00142-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Novel protective effect of the FOXO3 longevity genotype on mechanisms of cellular aging in OkinawansPMID 38459055Read ↗

Minimal Shortening of Leukocyte Telomere Length Across Age Groups in a Cross-Sectional Study for Carriers of a Longevity-Associated FOXO3 Allele.Semantic proximity Read ↗

Association between FOXO3A gene polymorphisms and human longevity: a meta-analysis.Semantic proximity Read ↗

Longevity-Associated FOXO3 Genotype and its Impact on Coronary Artery Disease Mortality in Japanese, Whites, and Blacks: A Prospective Study of Three American Populations.Semantic proximity Read ↗

FOXO3 longevity genotype mitigates the increased mortality risk in men with a cardiometabolic disease.Semantic proximity Read ↗

Genetic Association Analysis of Common Variants in FOXO3 Related to Longevity in a Chinese Population.Semantic proximity Read ↗

The Association Between Longevity-Associated FOXO3 Allele and Heart Disease in Septuagenarians and Octogenarians: The SONIC Study.Semantic proximity Read ↗

Proteomic basis of mortality resilience mediated by FOXO3 longevity genotype.Semantic proximity Read ↗

rs2802292 polymorphism in the FOXO3A gene and exceptional longevity in two ethnically distinct cohorts.Semantic proximity Read ↗

The FoxO3 gene and cause-specific mortality.Semantic proximity Read ↗

Genetic factors and epigenetic mechanisms of longevity: current perspectives.Semantic proximity Read ↗

FOXO3A genotype is strongly associated with human longevity.Semantic proximity Read ↗

Identification and characterization of two functional variants in the human longevity gene FOXO3.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.