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Article

Proteomic basis of mortality resilience mediated by FOXO3 longevity genotype.

GeroScience - 1 Aug 2023

Donlon Timothy A, Morris Brian J, Chen Randi, Lim Eunjung, Morgen Eric K, Fortney Kristen, Shah Naisha, Masaki Kamal H, Willcox Bradley J

Abstract excerpt

FOXO3 is a ubiquitous transcription factor expressed in response to cellular stress caused by nutrient deprivation, inflammatory cytokines, reactive oxygen species, radiation, hypoxia, and other factors. We showed previously that the association of inherited FOXO3 variants with longevity was the result of partial protection against mortality risk posed by aging-related life-long stressors, particularly...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 36881352
DOI: 10.1007/s11357-023-00740-6
PMCID: PMC10651822

Genes

FOXO3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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