Article
Minimal Shortening of Leukocyte Telomere Length Across Age Groups in a Cross-Sectional Study for Carriers of a Longevity-Associated FOXO3 Allele.
The journals of gerontology. Series A, Biological sciences and medical sciences - 8 Oct 2018
Davy Philip M C, Willcox D Craig, Shimabukuro Michio, Donlon Timothy A, Torigoe Trevor, Suzuki Makoto, Higa Moritake, Masuzaki Hiroaki, Sata Masataka, Chen Randi, Murkofsky Rachel L, Morris Brian J, Lim Eunjung, Allsopp Richard C, Willcox Bradley J
Abstract excerpt
FOXO3 is one of the most prominent genes demonstrating a consistently reproducible genetic association with human longevity. The mechanisms by which these individual gene variants confer greater organismal lifespan are not well understood. We assessed the effect of longevity-associated FOXO3 alleles on age-related leukocyte telomere dynamics in a cross-sectional study comprised of samples from 121 healthy...
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