Article
ARID1A orchestrates SWI/SNF-mediated sequential binding of transcription factors with ARID1A loss driving pre-memory B cell fate and lymphomagenesis.
Cancer cell - 8 Apr 2024
Barisic Darko, Chin Christopher R, Meydan Cem, Teater Matt, Tsialta Ioanna, Mlynarczyk Coraline, Chadburn Amy, Wang Xuehai, Sarkozy Margot, Xia Min, Carson Sandra E, Raggiri Santo, Debek Sonia, Pelzer Benedikt, Durmaz Ceyda, Deng Qing, Lakra Priya, Rivas Martin, Steidl Christian, Scott David W, Weng Andrew P, Mason Christopher E, Green Michael R, Melnick Ari
Abstract excerpt
ARID1A, a subunit of the canonical BAF nucleosome remodeling complex, is commonly mutated in lymphomas. We show that ARID1A orchestrates B cell fate during the germinal center (GC) response, facilitating cooperative and sequential binding of PU.1 and NF-kB at crucial genes for cytokine and CD40 signaling. The absence of ARID1A tilts GC cell fate toward immature IgM+CD80-PD-L2- memory B cells, known for their...
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