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Article

ARID1A mutations protect follicular lymphoma from FAS-dependent immune surveillance by reducing RUNX3/ETS1-driven FAS-expression.

Cell death and differentiation - 1 May 2025

Antoniolli Martina, Solovey Maria, Hildebrand Johannes Adrian, Freyholdt Tabea, Strobl Carolin Dorothea, Bararia Deepak, Keay William David, Adolph Louisa, Heide Michael, Passerini Verena, Winter Lis, Wange Lucas, Enard Wolfgang, Thieme Susanne, Blum Helmut, Rudelius Martina, Mergner Julia, Ludwig Christina, Bultmann Sebastian, Schmidt-Supprian Marc, Leonhardt Heinrich, Subklewe Marion, von Bergwelt-Baildon Michael, Colomé-Tatché Maria, Weigert Oliver

Abstract excerpt

The cell death receptor FAS and its ligand (FASLG) play crucial roles in the selection of B cells during the germinal center (GC) reaction. Failure to eliminate potentially harmful B cells via FAS can lead to lymphoproliferation and the development of B cell malignancies. The classic form of follicular lymphoma (FL) is a prototypic GC-derived B cell malignancy, characterized by the t(14;18)(q32;q21)IGH::BCL2...

Read the complete abstract on PubMed

Topics

Humans
Lymphoma, Follicular
fas Receptor

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

DNA-Binding Proteins

Transcription Factors

Mutation

Core Binding Factor Alpha 3 Subunit

Proto-Oncogene Protein c-ets-1

Cell Line, Tumor

Female

Male

Nuclear Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 39843653
DOI: 10.1038/s41418-025-01445-3
PMCID: PMC12089402

Genes

ARID1A
FAS
BCL2
RUNX3
ETS1
FASLG
GC
IGH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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