Article

<i>ARID1A</i> Mutations Protect Follicular Lymphoma from FAS-dependent Immune Surveillance by Reducing RUNX3/ETS1-Driven FAS-Expression

2023-12-13

Abstract excerpt

<h4>ABSTRACT</h4> The cell death receptor FAS and its ligand (FASLG) play crucial roles in the selection of B cells during the germinal center (GC) reaction. Failure to eliminate potentially harmful B cells via FAS can lead to lymphoproliferation and the development B cell malignancies. The classic form of follicular lymphoma (FL) is a prototypic GC-derived B cell malignancy, characterized by the t(14;18) (q32;q2...

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Literature Corpus work: 2e4f1b21-6fea-5cf2-8b67-21cc53da4271
DOI: 10.1101/2023.12.12.571212

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