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Tuning of plasma cell lifespan by competition explains the longevity and heterogeneity of antibody persistence

1 Mar 2024

Abstract excerpt

Plasma cells that emerge after infection or vaccination exhibit heterogeneous lifespans; most survive for days to months, whereas others persist for decades, providing antigen-specific long-term protection. We developed a mathematical framework to explore the dynamics of plasma cell removal and its regulation by survival factors. Analyses of antibody persistence following hepatitis A and B and HPV vaccination...

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Share to Complement system in diseases
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PMID: 38447570
DOI: 10.1016/j.immuni.2024.02.005

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