Article

Non-equilibrium antigen recognition in acute infections

2023-04-06

Abstract excerpt

The immune response to an acute primary infection is a coupled process of antigen proliferation, molecular recognition by naive B-cells, and their subsequent proliferation and antibody shedding. Here we show B-cells can efficiently recognise new antigens by a tuned kinetic proofreading mechanism, where the number of proofreading steps and the characteristic rate of each step are set by the complexity of the immune...

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Literature Corpus work: 36f5415f-a3bf-58f7-bae7-32d5f7c8f464
DOI: 10.1101/2023.04.05.535743

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