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Article

Contributions of transcriptional noise to leukaemia evolution: KAT2A as a case-study.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences - 22 Apr 2024

Pina Cristina

Abstract excerpt

Transcriptional noise is proposed to participate in cell fate changes, but contributions to mammalian cell differentiation systems, including cancer, remain associative. Cancer evolution is driven by genetic variability, with modulatory or contributory participation of epigenetic variants. Accumulation of epigenetic variants enhances transcriptional noise, which can facilitate cancer cell fate transitions. Acute...

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Identifiers

PMID: 38432321
DOI: 10.1098/rstb.2023.0052
PMCID: PMC10909511

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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