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Article

Tissue disruption increases stochastic gene expression thus producing tumors: Cancer initiation without driver mutation.

International journal of cancer - 1 Jun 2017

Capp Jean-Pascal

Abstract excerpt

Cancer research produced many paradoxical results in recent years. The reductionist approach now shows its limits. Considering the origin of the disease at the tissue level and increased stochastic gene expression (SGE) as a driving force, while admitting a role for genetic alterations in cancer progression, might solve these contradictions. Undifferentiated cells are characterized by open and accessible...

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Share to Cell Differentiation
Share to Cell Transformation, Neoplastic
Share to Epigenesis, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 28052327
DOI: 10.1002/ijc.30596

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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