Article

The role of non-genetic variability in Acute Myeloid Leukaemia

2021-01-01

Abstract excerpt

Acute myeloid leukaemia (AML) is a heterogeneous clonal disorder of haematopoietic progenitor cells with a dismal survival. It has a strong reliance on epigenetic and transcriptional factors for disease progression. Accordingly, my lab has previously identified KAT2A, a histone acetyl-transferase, as a requirement for AML maintenance, where chemical inhibition of KAT2A promotes differentiation of AML cell lines (T...

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Literature Corpus work: 289cd830-f85e-5a44-9d77-d383e8188c47
DOI: 10.17863/cam.72081

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