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Article

Genome-wide analysis of aberrant methylation of enhancer DNA in human osteoarthritis

3 Jan 2020

Abstract excerpt

BACKGROUND: Osteoarthritis is a chronic musculoskeletal disease characterized by age-related gradual thinning and a high risk in females. Recent studies have shown that DNA methylation plays important roles in osteoarthritis. However, the genome-wide pattern of methylation in enhancers in osteoarthritis remains unclear. METHODS: To explore the function of enhancers in osteoarthritis, we quantified CpG methylation...

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Share to Epigenetics and DNA Methylation
Share to Genomics and Chromatin Dynamics
Share to Osteoarthritis Treatment and Mechanisms

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PMID: 31900157
DOI: 10.1186/s12920-019-0646-9

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