Article
Diffsig: Associating Risk Factors with Mutational Signatures.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 May 2024
Park Ji-Eun, Smith Markia A, Van Alsten Sarah C, Walens Andrea, Wu Di, Hoadley Katherine A, Troester Melissa A, Love Michael I
Abstract excerpt
BACKGROUND: Somatic mutational signatures elucidate molecular vulnerabilities to therapy, and therefore detecting signatures and classifying tumors with respect to signatures has clinical value. However, identifying the etiology of the mutational signatures remains a statistical challenge, with both small sample sizes and high variability in classification algorithms posing barriers. As a result, few signatures...
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