Article

SigDyn: single-cell mutational signature dynamics

2026-01-22

Abstract excerpt

<h4>Motivation</h4> Cancer is driven by mutations that confer tumor cells proliferation advantages but also vulnerabilities with therapeutic potential. Underlying tumor progression are mutational processes that imprint signatures of co-occurring mutation types in tumor cell genomes. The discovery of signatures and their etiologies offers insight into disease mechanisms and treatment opportunities, however acquisi...

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Literature Corpus work: eab11b17-3f4c-5651-a1a0-876333b82f89
DOI: 10.64898/2026.01.20.700537

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