Article
decompTumor2Sig: identification of mutational signatures active in individual tumors
1 Apr 2019
Abstract excerpt
BACKGROUND: The somatic mutations found in a tumor have in most cases been caused by multiple mutational processes such as those related to extrinsic carcinogens like cigarette smoke, and those related to intrinsic processes like age-related spontaneous deamination of 5-methylcytosine. The effect of such mutational processes can be modeled by mutational signatures, of which two different conceptualizations exist:...
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