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Bivalent mRNA COVID vaccines elicit predominantly cross-reactive CD4+ T cell clonotypes

28 Feb 2024

Abstract excerpt

Bivalent COVID vaccines containing mRNA for ancestral and Omicron BA.5 spike proteins do not induce stronger T cell responses to Omicron BA.5 spike proteins than monovalent vaccines that contain only ancestral spike mRNA. The reasons for this finding have not been elucidated. Here, we show that healthy donors (HDs) and people living with HIV (PLWH) on antiretroviral therapy mostly target T cell epitopes that are...

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PMID: 38423018
DOI: 10.1016/j.xcrm.2024.101442

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