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Article

SARS-CoV-2 Omicron BA.4/BA.5 Mutations in Spike Leading to T Cell Escape in Recently Vaccinated Individuals.

Viruses - 29 Dec 2022

Emmelot Maarten E, Vos Martijn, Boer Mardi C, Rots Nynke Y, van Els Cécile A C M, Kaaijk Patricia

Abstract excerpt

SARS-CoV-2 Omicron (B.1.1.529) lineages rapidly became dominant in various countries reflecting its enhanced transmissibility and ability to escape neutralizing antibodies. Although T cells induced by ancestral SARS-CoV-2-based vaccines also recognize Omicron variants, we showed in our previous study that there was a marked loss of T cell cross-reactivity to spike epitopes harboring Omicron BA.1 mutations. The...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 36680141
DOI: 10.3390/v15010101
PMCID: PMC9863717

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