Article

SARS-CoV-2 variants Omicron BA.4/5 and XBB.1.5 significantly escape T cell recognition in solid organ transplant recipients vaccinated against the ancestral strain

2023-08-21

Abstract excerpt

<h4>Background</h4> Immune-suppressed solid organ transplant recipients (SOTRs) display impaired humoral responses to COVID-19 vaccination, but T cell responses are incompletely understood. The highly infectious SARS-CoV-2 variants Omicron BA.4/5 and XBB.1.5 escape neutralization by antibodies induced by vaccination or infection with earlier strains, but T cell recognition of these lineages in SOTRs is unclear. <h...

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Literature Corpus work: e68cfc6a-5af0-5dcf-9bc9-cc8a4a79bb95
DOI: 10.1101/2023.08.14.23293991

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