Article
Bilateral Oophorectomy and All-Cause Mortality in Women With BRCA1 and BRCA2 Sequence Variations.
JAMA oncology - 1 Apr 2024
Kotsopoulos Joanne, Gronwald Jacek, Huzarski Tomasz, Møller Pål, Pal Tuya, McCuaig Jeanna M, Singer Christian F, Karlan Beth Y, Aeilts Amber, Eng Charis, Eisen Andrea, Bordeleau Louise, Foulkes William D, Tung Nadine, Couch Fergus J, Fruscio Robert, Neuhausen Susan L, Zakalik Dana, Cybulski Cezary, Metcalfe Kelly, Olopade Olufunmilayo I, Sun Ping, Lubinski Jan, Narod Steven A
Abstract excerpt
Importance: Preventive bilateral salpingo-oophorectomy is offered to women at high risk of ovarian cancer who carry a pathogenic variant in BRCA1 or BRCA2; however, the association of oophorectomy with all-cause mortality has not been clearly defined. Objective: To evaluate the association between bilateral oophorectomy and all-cause mortality among women with a BRCA1 or BRCA2 sequence variation. Design, Setting,...
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