Article
NFKB1 variants were associated with the risk of Parkinson´s disease in male.
Journal of neural transmission (Vienna, Austria : 1996) - 1 Jul 2024
Perez-Oliveira Sergio, Vazquez-Coto Daniel, Pardo Sara, Blázquez-Estrada Marta, Menéndez-González Manuel, Siso Pablo, Suárez Esther, García-Fernández Ciara, Fages Beatriz de la Casa, Coto Eliecer, Álvarez Victoria
Abstract excerpt
The NF-κB pathway is involved in the pathogenesis of neurological disorders that have inflammation as a hallmark, including Parkinson's disease (PD). Our objective was to determine whether common functional variants in the NFKB1, NFKBIA and NFKBIZ genes were associated with the risk of PD. A total of 532 Spanish PD cases (61% male; 38% early-onset, ≤ 55 years) and 300 population controls (50% ≤55 years) were...
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