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Article

Gene variants in the NF-KB pathway (NFKB1, NFKBIA, NFKBIZ) and their association with type 2 diabetes and impaired renal function.

Human immunology - 1 Jun 2018

Coto Eliecer, Díaz-Corte Carmen, Tranche Salvador, Gómez Juan, Alonso Belén, Iglesias Sara, Reguero Julián R, López-Larrea Carlos, Coto-Segura Pablo

Abstract excerpt

The NF-kappaB pathway might play a role in the pathogenesis of renal disease and type 2 diabetes (T2DM). Our aim was to determine whether common polymorphisms in NF-kappaB genes were associated with impaired renal function and T2DM in a cohort of healthy elderly individuals. We studied 487 individuals, all Caucasian and aged 65-85 years. A total of 104 (21%) had impaired renal function (estimated glomerular...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29601852
DOI: 10.1016/j.humimm.2018.03.008

Genes

NFKB1
NFKBIA
NFKBIZ

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