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Article

Genetic variants associated with autoimmunity drive NFκB signaling and responses to inflammatory stimuli.

Science translational medicine - 10 Jun 2015

Housley William J, Fernandez Salvador D, Vera Kenneth, Murikinati Sasidhar R, Grutzendler Jaime, Cuerdon Nicole, Glick Laura, De Jager Phillip L, Mitrovic Mitja, Cotsapas Chris, Hafler David A

Abstract excerpt

The transcription factor nuclear factor κB (NFκB) is a central regulator of inflammation, and genome-wide association studies in subjects with autoimmune disease have identified a number of variants within the NFκB signaling cascade. In addition, causal variant fine-mapping has demonstrated that...

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Identifiers

PMID: 26062845
DOI: 10.1126/scitranslmed.aaa9223
PMCID: PMC4574294

Genes

BCL3
TNFAIP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-26062845-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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