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Article

Mutation of SOCS2 induces structural and functional changes in mammary development.

Development (Cambridge, England) - 15 Mar 2024

Ivanova Elitsa, Hue-Beauvais Cathy, Castille Johan, Laubier Johann, Le Guillou Sandrine, Aujean Etienne, Lecardonnel Jerome, Lebrun Laura, Jaffrezic Florence, Rousseau-Ralliard Delphine, Péchoux Christine, Letheule Martine, Foucras Gilles, Charlier Madia, Le Provost Fabienne

Abstract excerpt

Lactation is an essential process for mammals. In sheep, the R96C mutation in suppressor of cytokine signaling 2 (SOCS2) protein is associated with greater milk production and increased mastitis sensitivity. To shed light on the involvement of R96C mutation in mammary gland development and lactation, we developed a mouse model carrying this mutation (SOCS2KI/KI). Mammary glands from virgin adult SOCS2KI/KI mice...

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Share to Epithelial Cells
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 38391249
DOI: 10.1242/dev.202332

Genes

SOCS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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