Article
Deletion of Stat3 blocks mammary gland involution and extends functional competence of the secretory epithelium in the absence of lactogenic stimuli.
Endocrinology - 1 Sept 2002
Humphreys Robin C, Bierie Brian, Zhao Ling, Raz Regina, Levy David, Hennighausen Lothar
Abstract excerpt
The transcription factor Stat3 is activated through tyrosine phosphorylation by many cytokines and is a fundamental mediator of their signals. In the mammary gland, Stat3 activity increases sharply shortly after weaning, and involution is delayed in mice, that contain a mutant Stat3 lacking 33 amino acids including the key tyrosine residue. We have now generated a more extensive mutation of Stat3 through the...
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