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The SOCS1 KIR and SH2 domain are both required for suppression of cytokine signaling in vivo

17 Mar 2023

Abstract excerpt

Suppressor Of Cytokine Signaling (SOCS) 1 is a critical negative regulator of cytokine signaling and required to protect against an excessive inflammatory response. Genetic deletion of Socs1 results in unrestrained cytokine signaling and neonatal lethality, characterised by an inflammatory immune infiltrate in multiple organs. Overexpression and structural studies have suggested that the SOCS1 kinase inhibitory...

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PMID: 36934508
DOI: 10.1016/j.cyto.2023.156167

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