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Article

ZnT4 (SLC30A4)-null ("lethal milk") mice have defects in mammary gland secretion and hallmarks of precocious involution during lactation.

American journal of physiology. Regulatory, integrative and comparative physiology - 1 Jan 2016

McCormick Nicholas H, Lee Sooyeon, Hennigar Stephen R, Kelleher Shannon L

Abstract excerpt

During lactation, highly specialized secretory mammary epithelial cells (MECs) produce and secrete huge quantities of nutrients and nonnutritive factors into breast milk. The zinc (Zn) transporter ZnT4 (SLC30A4) transports Zn into the trans-Golgi apparatus for lactose synthesis, and across the apical cell membrane for efflux from MECs into milk. This is consistent with observations in "lethal milk" (lm/lm) mice,...

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PMID: 26538236
DOI: 10.1152/ajpregu.00315.2014
PMCID: PMC4796636

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STAT3
TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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